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Research of Quantitative Relation between Insulin and Bone Mechanical Characteristics of Type ¢ñ Diab

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Tutor: GuoTongTong
School: Harbin Institute of Technology
Course: Mechanics
Keywords: osteoporosis,insulin,Type1diabetes,biochemical indicators,mechanicalproperties,q
CLC: R587.1
Type: Master's thesis
Year:  2012
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Abstract:
Insulin-dependent diabetes mellitus caused by Islet ¦Â-cell destruction will lead toosteoporosis, which is a metabolic bone disease characterized by decrease of bone mass,damage of bone microstructure, diminishment of bone strength, increase of bonefragility and fracture risk. Diabetic osteoporosis (Diabetic osteoporosis, DOP) is seriouscomplication that appears in the skeletal system with diabetes, and becomes the mainreason of a long-term severe pain and dysfunction. Currently, most of type ¢ñ diabetesosteoporosis research focused on qualitative research, the changes of variousbiochemical indicators and mechanical indicators have no periodic quantitativemeasurement. Further, quantitative relationship between biochemical indicators andmechanics indicators haven¡¯t had been built. In this study, the periodic quantitativechange process of biochemical parameters and mechanical indicators will be measured,and a quantitative relationship between the biochemical indicators and mechanicalindicators will be established, which is the foundation for type ¢ñ diabetes osteoporosisquantitative research.In this article, the research method will be animal experiments for quantitativeanalysis. We will get the serum and femur used in the experiment through animal¡¯sbreeding. Animal serum will be measured by enzyme-linked immunosorbent assay(micro plate-reader), in order to get the type ¢ñ diabetes bone osteoporosis-relatedbiochemical indicators¡¯ value in different periods, in different diseased rats (bothnormal and diseased rats), and on the basis of measurements, trend of biochemicalindicators over time will bi made, and comparative analysis will be made also.Compression test of rat femur will be made through the push and pull instrument, ratfemur macroscopic force and displacement data will be got. Force and displacementcurves will be mapped out through the resulting data and the differences of macroscopicelastic modulus between normal rats and diseased rats. Femoral cortical bonemicrostructure elastic modulus and micro-hardness will be measured be Nanoindentor,and there trends will be analysis. Based on the quantitative measurement of biochemicalindicators and mechanical index, the curves between biochemical Indicators andmechanics indicators will be got by Curve fitting. A quantitative relationship betweenbiochemical indicators and mechanics indicators will be established.In this thesis, on the basis of existing qualitative research, mechanical indicators and biochemical indicators of type ¢ñ diabetes osteoporosis rats will be measuredregularly, quantitative data of the whole sick process will be improved. The trends ofbiochemical parameters and mechanical indicators of type ¢ñ diabetes osteoporosis ratswill be drew out in the whole sick process. A quantitative relationship betweenbiochemical parameters and mechanical index will be established.This research will be able to provide a quantitative basis for biochemical indicatorsand mechanical indicators of type ¢ñ diabetes osteoporosis in the whole sick process. Aswell as provide a quantitative basis of the relationship between the biochemical markersand mechanical indicators of type ¢ñ diabetes osteoporosis, and guide the treatment oftype ¢ñ diabetes osteoporosis.
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